He also said the number of fatalities rose to 2,696 overnight from 2,182.
3,794 patients have been discharged from hospitals after being cured in the country, according to the minister.
At least 2,636 people hospitalized are in intensive care, including 1,050 in the Community of Madrid and more than 350,000 tests for COVID-19 have been conducted.
Since March 13, there have been registered cases in the 50 provinces of the country. Only on the islands of La Graciosa and Formentera has there been no registered positive cases.
The pandemic was confirmed to have spread to Spain on 31 January 2020, when a German tourist tested positive for SARS-CoV-2 in La Gomera, Canary Islands.
On 24 February, following a COVID-19 outbreak in Italy, Spain confirmed multiple cases related to the Italian clusters, originating from a medical doctor from Lombardy, Italy, who was on holiday in Tenerife.
Afterwards, multiple COVID-19 cases were detected in Tenerife involving people who had come in contact with the doctor. Other cases involving individuals who visited Italy were also discovered in mainland Spain.
ILKHA